The pharmaceutical and medical device industries are subject to the most stringent quality requirements. Healthcare and patient safety always come first.

Technological advances in automation and robotics are enabling the pharmaceutical industry to increase the speed and accuracy of their processes such as filling, packaging, and inspection. Deploying automation can help pharmaceutical companies to follow stringent regulatory and compliance standards, in addition to reducing operational costs.

Automation is inevitable and ever expansive. As technology continues to advance, automation shows the potential to transform processes and introduce performance improvements. In the pharmaceutical industry, the use of automation also reduces the chance of human error through its capability to consistently perform repetitive tasks. Pharmaceutical companies have been integrating automation into specific processes like drug development, serialization, anti-counterfeiting, and more. In manufacturing examples, automation has become prevalent in processes such as kit assembly, sortation, machine tending, and packaging.

There are countless benefits to using automation and robotics in pharmaceutical development and production. Some of the most notable advantages include:

• Efficiency. Robots can perform repetitive tasks at greater speeds than human workers alone. Automated solutions can also accommodate 24-hour production cycles, and are typically easy to implement.
• Accuracy. Automated equipment doesn’t need a learning curve to master weighing, blending, and tableting of solids, or the stirring and filling of liquids. Automation eliminates human error and significantly reduces product defects.
• Visibility. Automation solutions facilitate end-to-end tracking from material sourcing through final delivery. Electronic batch records, RFID technologies, and workflow management can help identify inefficiencies and correct them anywhere in the supply chain.
• Analytics. Advanced data analytics can be used to identify market trends and facilitate accurate forecasting. Analytics can also be implemented to improve processes and predict the effectiveness of potential changes.
• Reduced contamination. With less human interaction during production and handling, the risk of product contamination is significantly lessened.
• Return on investment. Automated systems provide energy savings, improved product quality, and faster production. These positive impacts on the bottom line ensure that the upfront costs of automation technology will be returned exponentially over the service life of the equipment.

The sanitary product range offers a wide range of tubes and fittings with an internal surface finish from Ra < 0.375 μm to Ra < 1.6 μm which is meet the requirement of DIN, ISO, BS, and ASME. They are designed to ensure dimensional accuracy and structural integrity and making it easy to install. It is required in biotechnology and pharma, personal care, food and beverage, dairy, and cosmetics.

Ultrafiltration (UF) is a variety of membrane filtration in which hydrostatic pressure forces a liquid against a semi permeable membrane. Suspended solids and solutes of high molecular weight are retained, while water and low molecular weight solutes pass through the membrane. The pore size of the ultrafiltration membrane is usually 103 – 106 Daltons.

Ultrafiltration (UF) is a pressure-driven barrier to suspended solids, bacteria, viruses, endotoxins and other pathogens to produce water with very high purity and low silt density.

Ultrafiltration (UF) is a variety of membrane filtration in which hydrostatic pressure forces a liquid against a semi permeable membrane. Suspended solids and solutes of high molecular weight are retained, while water and low molecular weight solutes pass through the membrane. Ultrafiltration is not fundamentally different from reverse osmosis, microfiltration or nanofiltration, except in terms of the size of the molecules it retains.

A membrane or, more properly, a semi permeable membrane, is a thin layer of material capable of separating substances when a driving force is applied across the membrane. Once considered a viable technology only for desalination, membrane processes are increasingly employed for removal of bacteria and other microorganisms, particulate material, and natural organic material, which can impart color, tastes, and odors to the water and react with disinfectants to form disinfection byproducts (DBP).

Ultrafiltration systems contain extremely fine membrane filters which need to be properly cleaned. The cleaning process used depends on whether a UF system is being used to remove organic or inorganic contaminants, or even both. To remove organic contaminants the general cleaning protocol for the cleaning of tubular membranes is to use a low foam, medium alkaline detergent at 0.6% to 1% for a maximum of 40 to 60 minutes. To remove inorganic contaminants the best treatment is with citric acid at a maximum concentration of 3.0 %. The acid should circulate for 1 to 3 hours. Hydrochloric acid can also be used to clean membranes, as can oxalic, sulfuric, and nitric acid.

A tablet press is a mechanical device that compresses powder into tablets of uniform size and weight. A tablet press can be used to manufacture tablets of a wide variety of materials, including pharmaceuticals, nutraceuticals, cleaning products, industrial pellets, and cosmetics. The basic principle behind the tablet compression machine is hydraulic pressure. This pressure is transmitted unreduced through the static fluid. Any externally applied pressure is transmitted via static fluid to all the directions in the same proportion. It also makes it possible to multiply the force as needed.

As the punch head touches the pre-compression roller, the Air Compensator allows the roller to lift until the required compression force is achieved. By measuring the displacement of the roller using a Linear Variable Displacement Transducer (LVDT), it is possible to measure the height of the tablet at pre-compression and, according to a strictly linear relationship, the weight. Similarly, by adjusting the pressure in the Air Compensator, it’s possible to adjust both the compression force and the dwell time without reducing the linear speed of the machine. The same principle can be applied at main compression to maintain a constant density/porosity on some of the press models.

Every application is different and tablet presses need to be set according to the characteristics of the material feed and the specific production requirements. The Air Compensator enables fine adjustments to be made to all operational parameters; thus, users can achieve the desired security of outcome without compromising on machine speed and plant productivity. The main compression Air Compensator also acts as an effective tooling-protection device should compression forces rise above tolerances.

Tablet coating machine is an equipment that coats the external surface of a tablet using a thin film of coating material. Working principle is relatively simple where the application of coating material is done on a moving bed of tablets and removing rapidly the solvent using a current of hot air.

The tablet to be coated are placed in a closed drum which is made to rotate continuously in an orbital manner under the influence of a streamlined plate. During the orbital motion of the tablets, the coating medium sprays automatically in a rational manner to avoid excess coating on the tablets.

Angled baffles are also fitted into the drum and air flow is provided which acts to mix the tablets. The baffles cause the tablets to be lifted and turned from the sides of the drum and onto the center of exposing all the sides of the tablets to the sprayed coating. Whilst the spraying is going on, hot air is introduced from the 50% perforated tablet bed which causes rapid drying of the coating medium. The hot air comes from inlet fan and is regulated in terms of temperature and volume.

Coating machines allows the drug release to be regulated. This ensures that the drug is supplied to the body in safe amounts that the body can handle and optimizes their effect on the body. The coating also increases the stability of the tablets which prevents oxidative degeneration caused by factors that may react with the drug such as light and air.

Another advantageous factor is that the tablets can easily be swallowed as they overcome the poor taste the tablets may have. The coating may be flavored or tasteless. This is because some tablets taste bitter or may not have a very pleasant taste.

The coating also gives the tablets its signature color which allows for easy identification and compatibility with other drugs. The coating also protects the drug from a gastric environment allowing it to reach the area in which it is intended for absorption.

The types of tablet coating are sugar coated which is used for kids, film coated which is most commonly used coating in the pharma industry today, gelatin coated is used to create a rich protein-based coating, enteric coated provide stomach acid resistant coat for the tablets that have an ingredient that is sensitive to acid, compression coating involve compaction of granular particles around a preformed tablet using special equipment through a dry process.

The Purified Water (PW) is mainly used for high demand water standard such as electronics, pharma, health products, food and beverages. The raw water needs to meet the drinking water standard. After filtration, Reverse Osmosis (RO), sterilization, and other processes, the Purified Water is pumped to the water point through external transfer to complete the whole preparation process. The system is made of Stainless Steel and can be effectively rust-proof. It is equipped with advanced technology of Reverse Osmosis and equipped with sterilizing devices before water point to improve water safety to meet needs of hospital, pharma industry, health products, food and IV solution production. The disinfection methods of pharma Purified Water equipment system include ozone disinfection.

The water distribution system is designed according to the actual needs of customers and disinfection requirements based on cGMP, ISPE engineering guidelines, and FDA specifications. It is with frame structure, space saving, plug and play, easy installation, pre-installation, and operation confirmation in manufacturing plant. All pipes are Stainless Steel 316L (SS-316L) with minimum grade 3A upto SF-4 with no dead angle. Sanitary connection all products can achieve temperature control, avoid bacteria breeding, and meet FDA requirements.

Pure Steam is usually steam prepared from Purified Water by Pure Steam Generator or the first effect evaporator of multi-effect distilled water machine. Both de-ionized water and Purified Water can be used as raw water of Pure Steam Generator. After evaporation, separation (removal of pollutants such as particulate and bacterial endotoxin), they can be transfer to the point of use under certain pressure.

Blister packaging is a pre-formed plastic packaging that uses a backing card which usually has some featured artwork on it and a clear plastic pocket known as the blister. Blister packaging consists of two primary components i.e., i) the cavity - made from either plastic or aluminum foil and ii) the lid made from paperboard, paper, plastic, or aluminum. The cavity contains the product, and the lid seals the product in the package. In pharmaceutical industry blister packaging is used to pack tablets, pills, capsules, granules. Clear plastic is used for packing the items and aluminum foils coated with adhesive bonding are used in the film which are heated together to form a separate sealed package. Blister packs can provide barrier protection for shelf-life requirements, and a degree of tamper resistance.

In blister packaging two different types of plastic materials viz. poly-vinyl chloride (PVC), PET polyethylene terephthalate (PET), amorphous polyethylene terephthalate (APET), high density polyethylene (HDPE), acrylonitrile butadiene styrene (ABS) etc. and aluminum sheets or foils are mainly used. In pharmaceutical industry two basic types of blister packages are used. In the first type, the cavity is constructed of clear, thermoformed plastic and the lid is formed of clear plastic or a combination of plastic, paper, and or foil. The second type of blister package contains foil as an essential component of both webs, and its cavity and is created by cold stretching.

The most advantage of blister packaging for the patients is the convenient and easy removal of tablets or capsules by pressing blister and forcing the contents to backing strip. The other advantages of blister packing are as follows:

1. Freshness. Particularly for items that are used one at a time, having individual compartments can keep them at the ready for whenever the consumer is ready. Herbs, medications, and other environmentally sensitive items may benefit from blister packaging for this reason.
2. Dosage or serving size. For medicines and certain foods, these packages evenly portion out an item so that the consumer does not use too much of the product at once. Some seasoning blends benefit from blister packs because the company has already predetermined the amount needed for certain recipes. In a similar manner, medicine dosing is easier to understand and safer for the consumer when this type of package is used.
3. Packaging materials. Aesthetically, a plastic blister container is a good choice because it provides the product with a range of options for creating a visually appealing and texturally pleasing experience. Generally, plastic and cardboard are used in commercial applications. In the pharmaceutical industry, plastic and aluminum is normally the best choice to keep the product fresh.
4. Visibility. With a plastic front, these containers allow consumers to view the product before purchasing. Doing so provides reassurance the amount of product contained is as advertised and that all pieces are accounted for. Even though customers can view the item, they cannot touch them. As such, the product is safeguarded from thieves and tampering.
5. Security. For items that need to remain immobilized, the blister pack is an ideal solution. The individualized and generally small compartments do not allow for the movement of product within the packaging. This design protects items from damage caused in transit.
6. Customization. Because all plastic blisters are thermoformed, every design is unique to the product being sold. Regardless of the size or number of items contained in the blister pack, it can be customized to fit the needs of the product.

Cleanroom safety and functionality is always our priority. However, we also work with customers to deliver flexible cleanroom designs that are capable of being adapted to suit the fast-changing nature of the pharma industry manufacturing process.

Among all the solid dosage forms, capsules are the second most popular dosage form to compressed tablets on the market. However, capsules have frequently been considered as the first dosage form used in early clinical trials of a new drug for several reasons. Because of the pressure to expedite the formulation development and manufacture of clinical trial materials, capsules have been proven the best choice for powder filling and the most suitable dosage form for blinding purposes. Capsules can also be used to mask the taste and odor of the active drug contained within the capsule shells.

The selection of excipients in the formula remains critical to ensure good flow properties and lubrication of the blend on a tamp-filling machine. The formula is to be encapsulated on a dosator-type machine, then the blend should also have some binding properties to facilitate plug formation for the transfer to the capsule shells. A capsule formulation should have satisfactory powder fluidity, lubrication, and compact ability for a successful manufacturing operation. The design of formulations also requires disintegration properties to promote de-aggregation of the powder mass into primary drug particles and speed up the dissolution rate of the drug substance.

Capsule filling machine is the one which is used in the pharmaceutical industries for filling the empty capsules. Capsule filler machine is also known as encapsulation. Encapsulation is a mechanical device that is used at the industry level for filling the powder formed active material of pharmaceutical industries in the empty capsules. Capsule filler functioning is to fill the powder and then locking the capsule. A capsule filler machine is always used for filling the bulks of capsules. The capsule filling machine automatically ejects the capsule which is filled and locked in the machines.

The most advantage of fill capsule are:

• They are the lower power consumption machine.
• It is a scalable and high-speed filling machine.
• Capsule fill machines are fully GMP base compliances.
• Some Capsule filling machines are only used in Aseptic fill to weight.
• Capsule fill machine helps to prevent Pharma industries from the loss of the powder material to almost 90%.
• It is a highly flexible, accurate, and precise machine for the Pharma industries.

Pharmaceutical liquid filling machines expedite the manufacturing of liquid drug suspensions. Different filling machines use different mechanical methods to fill containers with the correct amount of liquid in a clean and efficient manner. There are four main filling machine principles:

1. Gravity filling, For lower viscosity or frothy liquids, gravity filling is often a simple and economical solution. This filling principle operates by storing the liquid above the bottles to be filled and allowing gravity to draw the liquid down. For this to work smoothly, the liquid has to be free flowing with a consistent viscosity, and it should not have any particles that could obstruct its movement through the machine. This system works on the volumetric filling principle, dispensing the same amount of liquid each time using a timed fill. This filling machine principle is well-suited to a wide range of industries, including food and beverage, specialty chemical and cosmetics and personal care, so long as the product is free-flowing and of a low enough viscosity.
2. Overflow filling, The overflow filling principle stands out for its ability to fill bottles to the same level, even if that results in slight variations in volume. Overflow filling works best with thin to medium viscosity products, and this method can fill bottles at a fast rate. Any leftover product left in the filling tubes is pushed back into the storage tank to prevent waste.
3. Piston filling, Piston filling systems are suitable for liquids ranging from thin viscosities to thick. They are also able to process semi-solids and liquids with particulates. They pump product into containers in very precise amounts, delivered from a bulk tank that can also be configured with a buffer tank utilizing a level-sensing float, a manifold with direct draw, or recirculation methods. We can also customize your equipment to make filling even more efficient, such as adding a heated hopper to a tabletop piston filler to warm up thicker liquids, making them flow more easily. Piston fillers are especially well-suited for higher-cost liquids that need to be dispensed in precise amounts with little waste.
4. Pump fillers are the powerhouses that can move even the thickest products, including those that drip, stretch or contain large chunks. This type of system also permits an easier change between different fill volumes, which is more convenient for a single operator who needs to fill containers of different sizes. As with piston fillers, pump fillers are available in industrial models as well as semi-automatic tabletop systems for new and growing enterprises.

While these filling machines can all handle a range of products, especially with customization, the best system for your business depends on the characteristics of the liquid you are packaging.

Pharmaceutical, biomedical, and biotechnology companies face a wide range of fire hazards, in their bulk chemical facilities, clean production facilities, laboratories, warehouses and electrical infrastructure. There are also specific building requirements to eliminate collateral dangers such as fumes or substances that may be harmful to workers. These dynamic factors increase the challenges posed to fire detection and fire suppression within the industry.

The demand, therefore, is in identifying the most efficient and effective system design for each specific fire threat according to each facility requirements. Challenges include contamination of products from smoke, heat or a water sprinkler system, low temperatures, high ceilings and density of products in storage. Yet another industry issue might involve fire protection systems for the handling and dispensing of combustible liquids, solids or other hazardous materials.

The overall solution for HVAC and clean room means blocking out and excluding all pollutants such as microparticles, harmful air, bacteria, within a certain space, reasonably distribute the overall plant structure in the area to meet the requirements of the production process. It controls the temperature, relative humidity, cleanliness, space height, room pressure, airflow velocity, airflow distribution, noise vibration, electric distribution, lighting, static electricity in the effective space within a certain area of requirements. It is a specially designed room and no matter how the external air condition exchange, the cleanliness, temperature, relative humidity, pressure, and other performance characteristics of the clean room can all maintain and ensure the original design requirements and environmental protection.

Heating, Ventilation, and Air Conditioning (HVAC) systems are critical systems that can affect the ability of a pharmaceutical facility to meet its objective of providing safe and effective products to patients. HVAC is tool for controlling the ambient environment around processes. Wherever a process is open to the environment the HVAC can directly impact product quality by controlling the migration of objectionable aerosols (e.g. viable and non-viable particles) that could become product contaminants. The good manufacturing practice (GMP) requirements for the prevention of contamination and cross-contamination are an essential design consideration of an HVAC system.

HVAC consumes from 50-80% of the energy in a typical clean manufacturing facility. The more highly classified the space, the higher the percentage of energy use. So, HVAC is a major target for sustainability efforts. The reality is that efficient and effective cleanroom HVAC go hand-in-hand. Some extra effort up-front can result in facilities that consume less energy, emit less carbon and cost less to operate than more traditional designs.

Laser printing, also referred to as laser etching, laser marking or laser writing, is used in the pharmaceutical industry to imprint a logo or other identifying mark onto the surface of a soft gel capsule or tablet. In the pharmaceutical industry, it’s important that your products be clearly labeled. This model of printers allows you to add your name, logo, dosage, or any other identifying information to your products. With pinpoint precision, the quality and crispness of our laser printers is unparalleled.

The pharmaceutical industry relies on accurate information about structures that can be targeted for research. To effectively study a sample or organism being prepared for analysis, it is useful to retain the integrity of a structure or organism. The industry also requires drugs that are easy to store and transport without being degraded and have a good shelf-life. One method that is especially suited to these needs is lyophilization.

Lyophilization involves freezing a substance and then removing any ice or solvent through sublimation, which turns it into vapor without passing through a liquid stage. This requires specialist equipment. There are three stages to the process:

1. Freeze – The sample is completely frozen, typically in a glass vial or flask.
2. Vacuum – This requires a deep vacuum which is significantly below the triple point of water (the lowest point where liquid, gas and solid forms of the material can coexist).
3. Drying – Energy in the form of heat is added, which causes sublimation.

Compared to other methods of product preparation, controlled lyophilization keeps the product at a low enough temperature to avoid changes in the characteristics and appearance of the dried product. This makes it a good method for the preservation of many different heat-sensitive materials. These include microbes, proteins, pharmaceuticals, plasma, and tissues.

Face seal is a seal in which the sealing surfaces are normal to the axis of the seal. Face seals are typically used in static applications and are used to prevent leakage in the radial direction with respect to the axis of the seal. Face seals are often located in a groove or cavity on a flange.

O-rings is used to prevent fluid or air from escaping as it acts as a sealing device. When the ring is squeezed between two surfaces, it takes up the clearance and then prevents any fluid or air from being released.

Expansion joints are vital components in most industrial plants. They are installed as flexible connections in pipe and duct systems to take up or compensate for thermal expansion, vibration, and misalignments.

Advancements in processing and generating technologies are being combined with high demands for efficiency. This, along with a clear orientation towards environmental protection, puts high demands on expansion joint designs.

We offer a complete range of liquid and gas-lubricated pump shaft seals including standard and engineered seals in single and multi-seal versions. It is a complete range of solutions for API-682 categories and arrangements.

Complete range of products compressors from a single source. Single, double, and tandem versions and tandem seals with intermedia labyrinths available. Sealing solutions for normal and sterile applications for agitators ensure the seals are rugged enough to deliver excellent cost and engineering performance in all major applicants.